Henrik Clausen

DDS (1981) and DSc (1990). Worked in the glycobiology field for 30+ years focusing on structure, biosynthesis and genetic regulation of complex carbohydrates. Studied with professor Sen-Itiroh Hakomori in Seattle (1983-90) on blood group related carbohydrates, glycosyltransferases and genes. Founded a glycobiology research group at the Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, in 1990, and since 2007 head of a Center of Excellence in Glycomics funded by University of Copenhagen and since 2012 the Danish National Research Foundation. Past member of scientific advisory boards and consultant for Neose Technologies and ZymeQuest. National representative for International Glycoconjugate Organization (IGO) and member of the Royal Royal Danish Academy of Sciences and Letters. Research focus is primarily protein glycosylation, where we have isolated, cloned, and expressed many of the human glycosyltransferases involved in the biosynthesis. Our interests are broad and include basic understanding of genetic regulation, and biosynthesis of protein glycosylation, Immunity to glycans and glycoproteins, consequences of deficiencies in glycosylation in diseases, and biomedical applications. We have developed strategies to isolate and characterize O-glycoproteomes of cells by use of nuclease-mediated gene engineering and a combination of lectin chromatography and mass spectrometry (SimpleCells). Applied broad genetic glycoengineering of mammalian cells for deconstruction of glycosylation capacities and design of optimal platform cells for recombinant therapeutics. We have further developed glycopeptide arrays with comprehensive chemoenzymatic synthesis of glycopeptides, and we are now developing cell-based glycan arrays.